We work together with large scale ALS consortia to understand the molecular underpinnings of neurodegenerative disease. Together, we discovered that ALS patient tissues display 3 distinct subtypes, reflecting neuronal stress (ALS-Ox), neuroinflammation (ALS-Glia), and TPD-43 pathology associated transposable elements (ALS-TE)

We use induced neural cell types to model the function of neurodegeneration associated genes and transposable elements (TEs). What are the causal factors that induce particular molecular changes? Which alterations reflect downstream effects?

We build computational genomics software for bulk and single-cell sequencing data. In particular, we focus on software for the inclusion of transposable elements (TEs) - an important part of our genomes, but left out of most analysis pipelines